Adial Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the treatment and prevention of addictions. The Company’s lead investigational new drug product, AD04, is currently in Phase 3 development as a genetically targeted therapeutic agent for the treatment of Alcohol Use Disorder (AUD). A Phase 2b clinical trial of AD04 for the treatment of AUD showed promising results in reducing frequency and quantity of drinking and heavy drinking with no overt safety concerns.
Genetically Targeted
Designed to reduce craving to effectively curb alcohol intake in those patients with the genetics expected to indicate a likely response to treatment with AD04
BRINGS 20+ YEAR TRACK RECORD OF CLINICAL USE
To date, clinical testing of AD04 has shown it to have a positive safety and tolerability profile with side effects similar to placebo.
Oral daily dosing
Our product candidate is intended to be easy to use since it is administered orally.
AUD is characterized by an urge to consume alcohol and an inability to control the levels of consumption
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DYK June is #MensHealthMonth? Adial Chief Medical Office @bankolekolej highlights factors that may increase the likelihood of developing ...#AlcholUseDisorder in men. https://youtu.be/auNYexMgCHo #AUD #Alcoholism $ADIL
#DYK In addition to the organ damage that alcohol causes, researchers found it can potentially cause damage to a person's DNA that persists, at ...least, for months after stopping drinking.
Alcohol addiction: Study reveals irrevocable changes to DNA triggering to consume even more - The Indian Wire
While excessive intake of Alcohol may result in a variety of pathological effects, including damage to the liver, ...
www.theindianwire.com
As more people are questioning their relationship with alcohol, @TheAtlantic's @katejulian explored the culture of drinking, its history in the ...world, and why we've seen a shift to heavy drinking in isolation.
America Has a Drinking Problem
A little alcohol can boost creativity and strengthen social ties. But there’s nothing moderate, or convivial, ab...
www.theatlantic.com
AD04 Ready to Enter Phase 3 in Targeted Groups
Adial has commenced a Phase 3 clinical trial using AD04 for the potential treatment of AUD in subjects with certain target genotypes.
Adial has created an investigational attendant diagnostic biomarker blood test for the genetic screening of patients with certain biomarkers that, as reported in the American Journal of Psychiatry (Johnson, et. al. 2011 & 2013), Adial believes make patients more likely to benefit from treatment with AD04.
Adial’s strategy is to integrate pre-treatment genetic screening into AD04’s label to create a patient-specific treatment in one integrated therapeutic offering. Adial’s goal is to develop a genetically targeted, effective and safe product candidate to treat AUD that does not require abstinence as part of the treatment.